Massimo Fioranelli
 
 
Mater Dei - Via A. Bertoloni, 34 - 00197 Roma - Tel. + 39 6 80220.1 - Fax +39 6 8084556 Italiano  Italiano   English  English 
11/01/2016 Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification The CARDIA Study
11/01/2016 Carnosine
08/01/2016 Minimum Vitamin D Dose Inadequate For Overweight African Americans
06/01/2016 Increased Vitamin C Linked To Reduced Risk Of Early Mortality
06/01/2016 Depression Higher In Men With Borderline Testosterone Levels
06/01/2016 Resveratrol, Quercetin Could Improve Safety Of Cancer Drug
05/01/2016 Melatonin Improves Mitochondrial Function In Rat Model Of Diabetes






 




Per visualizzare il video una volta aperto il portale di Marconi Channel, cliccare su Scienza & Tecnologia quindi selezioanre il video dalla playlist.


Per visualizzare il video una volta aperto il portale di Marconi Channel, cliccare su Scienza & Tecnologia quindi selezioanre il video dalla playlist.








Il Progetto Health Phone ® ha lo scopo di tutelare la salute del cittadino, mediante un sistema di georeferenziazione ed un cardiofrequenzimetro, il Sistema Health Phone ® è in grado di effettuare chiamate immediate di pronto soccorso al 118, e di inviare dati alle persone più prossime con indicazioni di pronto intervento.
continua ...




Il Progetto Universal Guide ® propone la realizzazione di una guida universale da implementare su sistemi smart-phone o palmari. Attraverso l’integrazione di più sistemi di georeferenziazione, interna (RFID, Wi-Fi) ed esterna (GPS, Wi-Fi), la Universal Guide ® sarà in grado di guidare l’utente, anche non normodotato, attraverso il rispetto dei principi sull’accessibilità, all’interno di un museo, di un edificio pubblico, di un ospedale.
continua ...



GRAZIE
ALLA TC CORONARICA,
IL CUORE “PARLA”
Dopo 30 anni l’era della coronarografia sembra avviarsi alla sua conclusione.
E si allontana anche l’incubo delle radiazioni. Adesso c’è una tecnica, TC coronarica, disponibile anche a Roma, non invasiva, finalmente non rischiosa, molto più affidabile, in grado di scoprire quello che fino ad oggi la coronarografia non riusciva a “vedere”.
continua ...










The SYNTAX Score is a unique tool to score complexity of coronary artery disease.
continue ...




If you are healthy and without diabetes, the Reynolds Risk Score is designed to predict your risk of having a future heart attack, stroke, or other major heart disease in the next 10 years.
continue ...




Salute/ Prevenzione infarto,
nuova strategia diagnostica
Mater Dei
Roma - 8 novembre 2010

Gli esami dicono che tutto e' a posto ma poco dopo l'infarto puo' arrivare. Oggi è possibile intervenire precocemente, prima che l'infarto arrivi, grazie ad una strategia diagnostica altamente innovativa messa a punto a Roma dall'équipe di Massimo Fioranelli e Paolo Pavone della Clinica Mater Dei. Un 'Modello diagnostico integrato' che ...











RAI - Cardiologia,
le novità diagnostiche

A Tg1 online, il professor Fioranelli, dell'Università Gugliemo Marconi, ha risposto alle domande degli utenti. Ha moderato Manuela Lucchini.

RAI - 26/10/2011




RAI - Storie di salute
Nel talk-show condotto da Luana Ravegnini si parlerà di "malattie cardiovascolari" con il Professor Fioranelli ma anche di "sovrappeso e diete" con il Professor Ticca.

RAI - 19 gennaio 2009



FUMO E INFARTO
Fumare di meno fa bene al cuore: da quando è in vigore la legge antifumo in Italia sono diminuiti anche gli infarti.
Tg1 - 13 febbraio 2008



NUOVE FRONTIERE
DELLA MEDICINA
Alcuni ricercatori americani hanno messo a punto una tecnica di rigenerazione dei tessuti del cuore attraverso le staminali.
Tg1 - 14 gennaio 2008



NOVITA' PER IL CUORE
Ricercatori britannici hanno scoperto farmaci capaci di limitare i danni provocati dall'infarto o dall'ipertensione al cuore degli anziani.
Tg1 - 5 settembre 2006







 


 

 

 

 

 

 

Coloro che volessero inviare contributi, suggerimenti, articoli, immagini filmati attinenti al contenuto del sito possono inviarli al seguente indirizzo: massimo.fioranelli@materdei.it. Se ritenuti idonei, verranno pubblicati a nome dell’autore. Verranno presi in considerazione solo materiali completi di referenze bibliografiche.





 11/01/2016   Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification The CARDIA Study   BACKGROUND High levels of apolipoprotein B (apoB) have been shown to predict atherosclerotic cardiovascular disease (CVD) in adults even in the context of low levels of low-density lipoprotein cholesterol (LDL-C) or non–highdensity lipoprotein cholesterol (non–HDL-C). OBJECTIVESThis study aimed to quantify the associations between apoB and the discordance between apoB and LDL-C or non–HDL-C in young adults and measured coronary artery calcium (CAC) in midlife. METHODSData were derived from a multicenter cohort study of young adults recruited at ages 18 to 30 years. All participants with complete baseline CVD risk factor data, including apoB and year 25 (Y25) CAC score, were entered into this study. Presence of CAC was defined as having a positive, nonzero Agatston score as determined by computed tomography. Baseline apoB values were divided into tertiles of 4 mutually exclusive concordant/discordant groups, based on median apoB and LDL-C or non–HDL-C. RESULTSAnalysis included 2,794 participants (mean age: 253.6 years; body mass index: 24.55 kg/m 2 ; and 44.4% male). Mean lipid values were as follows: total cholesterol: 177.333.1 mg/dl; LDL-C: 109.931.1 mg/dl; non–HDL-C: 124.033.5 mg/dl; HDL-C: 5312.8 mg/dl; and apoB: 90.7 24 mg/dl; median triglycerides were 61 mg/dl. Compared with the lowest apoB tertile, higher odds of developing Y25 CAC were seen in the middle (odds ratio [OR]: 1.53) and high (OR: 2.28) tertiles based on traditional risk factor–adjusted models. High apoB and low LDL-C or non–HDL-C discordance was also associated with Y25 CAC in adjusted models (OR: 1.55 and OR: 1.45, respectively). CONCLUSIONSThese data suggest a dose–response association between apoB in young adults and the presence of midlife CAC independent of baseline traditional CVD risk factors. (J Am Coll Cardiol 2016;67:193–201) © 2016 by the American College of Cardiology Foundation.

 11/01/2016   Carnosine   Carnosine is a multifunctional dipeptide made up of the amino acids beta-alanine and L-histidine.58 It is found both in food and in the human body. Long-lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine.58 Muscle levels of carnosine correlate with the maximum life spans of animals. Carnosine has been shown to be an anti-glycating agent. This nutrient has the ability to suppress formation of advanced glycation end products (AGEs). Carnosine levels decline with age. Muscle levels decline 63% from age 10 to age 70, which may account for the normal age-related decline in muscle mass and function. Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes. Aging causes damage to the body’s proteins. One underlying mechanism behind this damage is glycation. Glycation involves the non-enzyme controlled cross-linking of proteins or lipids and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as wrinkled skin. Glycation is also an underlying cause of age-related neurologic, vascular, and eye problems. Carnosine is a unique dipeptide that can interfere with the glycation process.

 08/01/2016   Minimum Vitamin D Dose Inadequate For Overweight African Americans   On July 4, 2015, the journal BioMed Central Obesitypublished the results of a trial of overweight and obese African Americans that revealed a failure of the Institute of Medicine’s recommended minimum daily dose of vitamin D to elevate serum levels to a healthy range after 16 weeks of treatment.* The trial included 70 overweight or obese African Americans between the ages of 13 to 45 years with 25 hydroxyvitamin D levels of 20 ng/mL or lower. Participants were randomized to groups that received a placebo or a monthly dose equivalent to 600 IU(international units), 2,000 IU, or 4,000 IUvitamin D per day for 16 weeks. While the two higher doses were successful at restoring serum vitamin D levels to 30 ng/ mLor more at 16 weeks, those who were given the lowest dose failed to achieve this level. In contrast, participants in the 2,000 and 4,000 IUequivalent group reached a serum level of 30 ng/mLas early as eight weeks. Otimal 25-hydroxyvitamin D levels are in the range of 50-80 ng/mL. * BMC Obes. 2014 Jul 4.

 06/01/2016   Increased Vitamin C Linked To Reduced Risk Of Early Mortality   The American Journal of Clinical Nutrition published findings from researchers at the University of Copenhagen of a lower risk of cardiovascular disease and premature death in association with increases in plasma vitamin C and fruit and vegetable intake.* The investigators analyzed data from 87,030 men and women enrolled in the Copenhagen General Population Study and 10,173 participants in the Copenhagen City Heart Study. Plasma vitamin C levels were measured in 3,512 newly recruited subjects and dietary intake data was available for 83,256 subjects. Ischemic heart disease was documented in 10,123 individuals and there were 8,477 deaths over the studies’ follow-up periods. “We can see that those with the highest intake of fruit and vegetables have a 15% lower risk of developing cardiovascular disease and a 20%lower risk of early death compared with those who very rarely eat fruit and vegetables,” reported lead author Camilla Kobylecki. “At the same time, we can see that the reduced risk is related to high vitamin C concentrations in the blood from the fruit and vegetables,” Dr. Kobylecki added. * Am J Clin Nutr.2015 Jun;101(6):1135-43.

 06/01/2016   Depression Higher In Men With Borderline Testosterone Levels   An article that appeared in the Journal of Sexual Medicine reports the findings of researchers at George Washington University of a greater risk of depression and depressive symptoms in men with borderline testosterone levels.* “In an era where more and more men are being tested for ‘low T’, or lower levels of testosterone,there is very little data about the men who have borderline low testosterone levels,” observed lead researcher Michael S. Irwig, MD. Dr. Irwig and his associates analyzed data from 200 men between 20 to 77 years of age who were referred for tertiary care for testosterone levels ranging from 200 to 350 ng/dL. Patient Health Questionnaire scores were used to determine the presence of depressive symptoms. The study results showed that, compared with the general population, men with borderline testosterone levels had a significantly higher rate of depression than the general population (56% versus 23%). Analysis showed that the study participants had higher rates of obesity and lower rates of physical activity than men in the general population. Study subjects also suffered from erectile dysfunction, decreased libido, fewer morning erections, low energy, and sleep disturbances. Rates of depression were 62% for study participants in their 20s and 30s, 65%for those in their 40s, 51%for those in their 50s and 45%f or those age 60 and over. Clinicians should consider screening for depression/depressive symptoms and overweight and unhealthy lifestyle risk factors in men referred for tertiary care for potential hypogonadism,” the authors conclude. We have long urged aging men to consider maintaining total testosterone levels in the range of 700-900 ng/dL, which is where younger, healthier men normally are. * J Sex Med. 2015 Jun 30

 06/01/2016  Resveratrol, Quercetin Could Improve Safety Of Cancer Drug   Findings described in the Journal of Controlled Release suggest that the polyphenols resveratrol and quercetin could help improve the safety of Adriamycin (doxorubicin), an effective but potentially cardiotoxic chemotherapy1. Adriamycin’s mechanism of cardiotoxicity involves reactive oxygen and nitrogen species generation, a phenomenon that is reduced by free radical scavengers such as these plant derived compounds. Using a system involving polymeric micelles to improve bioavailability, Adam Alani of Oregon State University’s College of Pharmacy and associates first tested the compounds in human ovarian cancer cells and rat heart muscle cells. While Adriamycin was antagonistic toward heart cells, resveratrol and quercetin decreased the activity of caspases (protein-degrading enzymes) involved in apoptosis (programmed cell death) in these cells while not interfering with Adriamycin’s caspase activity in cancerous cells. Reactive oxygen species generated in both cell lines were reduced by resveratrol and quercetin only in the heart muscle cells. When the combo was tested in mice, resveratrol and quercetin were shown to confer full cardioprotection. 1. J Control Release. 2015 Jul 6;213:128-33

 05/01/2016   abdominal fat   Few people realize that excess abdominal fat, especially excess fatty deposits around the internal organs in the abdominal cavity (called visceralbody fat), is far more damaging to health and longevity than simply being “overweight.” When excess abdominal fat accumulates, research indicates a strong correlation with cardiovascular disease, type II diabetes, and even some types of cancer. In addition, excessive abdominal fat is also associated with Alzheimer’s disease and osteoporosis. Studies reveal that excess fat stored in the abdomen is associated with a: 1,4,26 • 44%increase in cardiovascular disease risk, • 43%increase in cancer risk, • 233%increase in risk of death from all causes, • 700%increase in cardiovascular death risk, • 116%increase (in women) in the risk of a recurrent cardiovascular event of any kind following a known heart attac

 05/01/2016  Melatonin Improves Mitochondrial Function In Rat Model Of Diabetes   The Journal of Pineal Research published an article that reported a protective effect for melatonin on mitochondrial function in obese rats. “Because mitochondria are a target for melatonin action, the goal of this study was to investigate the effects of melatonin on mitochondrial function in white and beige inguinal adipose tissue of Zücker diabetic fatty rats,” write authors Ahmad Agil and colleagues. The team divided eight diabetic rats and eight lean littermates to receive melatonin-enhanced or plain drinking water for six weeks, after which mitochondrial function was evaluated. They observed improvement in mitochondrial respiration and a reduction in oxidative status among both lean and obese animals that received melatonin. “Melatonin is a natural substance present in plants, animals, and humans; it works as a hormonal signal released during the night to establish circadian rhythms,” said Dr. Agil.Melatonin is found in a number of plant foods, melatonin is available as an over-the-counter supplement. * J Pineal Res. 2014 Aug;57(1):103-9.

 03/01/2016   New Studies Show Metformin Is Indicated As A Potential Anticancer Drug   Numerous studies provide evidence of the anticancer effect of metformin.* A recent review published in PLOS Onefound an association between the diabetes medication and a significant reduction in the risk of colorectal, liver, pancreatic, stomach, and esophagus cancers in patients with myotonic dystrophy type II, an inherited disorder of the muscles and other body systems. A further study published in Cancer Prevention Researchfound that low doses of 250 mgper day of metformin administered for four weeks to nondiabetic patients suppressed markers for colorectal cancer. Metformin may impact cancer through indirect (insulin-dependent) and/or direct (insulin-independent) mechanisms. Metformin reduced lung tumor development primarily through an insulin-dependent mechanism by decreasing circulating levels of insulin-like growth factor-I (IGF). IGF activates its receptor, which in addition to a metabolic effect promotes proliferation and metastasis. The direct-insulin independent antitumor action of metformin is mainly induced by activating the AMPK signaling pathway, resulting in an inhibition of the mammalian target of rapamycin (mTOR), a signaling pathway that plays a central role in cancer cell growth, proliferation, and pathogenesis. The effects of metformin as a breast cancer target have been studied extensively. A study published in Cancer Researchfound that metformin targets cancer stem cell (tumor-initiating cells) in four genetically different kinds of breast cancer cell lines. Treatment with a low-dose of metformin was found to eliminate cancer stem cells, possibly due to the inhibition of the inflammatory pathway. This observation could be the definitive link between the diabetic drug and its anticancer benefits, since inflammation plays a key role in both diseases

 02/01/2016   Subnormal Selenium Levels Linked With Increased Mortality   The European Journal of Clinical Nutrition reported an association between decreased serum selenium levels and a greater risk of mortality in an older population over a period of 6.8 years.* The study included 449 older men and women who participated in an epidemiologic project in southeast Sweden. Serum selenium levels were measured upon enrollment in January 2003 and in 98 subjects after 48 months. Through February 2010, there were 122 deaths from all causes, including 85 that were attributable to cardiovascular disease. Among those whose selenium levels were among the lowest quartile of subjects, there was an adjusted 43%increase in the risk of dying from any cause and a 56%increased risk of cardiovascular mortality in comparison with the remainder of the study population that had higher serum seleniumlevels. Editor’s Note:“This result may suggest the value of modest selenium supplementation in order to improve the health of the Swedish population,” the authors conclude. * Eur J Clin Nutr.2015 Jun 24

 02/01/2016   SELENIUM BENEFITS   Selenium acts protecting DNA, eliminating toxins, boosting immunity, and optimizing thyroid function, the proper forms of selenium have been shown to impede heart disease, certain cancers, immune senescence, and premature death.

 30/12/2015   Higher Vitamin E Intake Linked To Lower Blood Pressure   An article published in the Journal of Nutritional Science and Vitaminology reveals an association between higher vitamin E intake and a reduced risk of hypertension.* Akiko Kuwabara and associates evaluated data from 1,405 men and 2,102 women aged 40 and older who participated in Japan’s National Health and Nutrition Survey 2007. Dietary records were analyzed for the intake of vitamin E and other nutrients. The presence of hypertension was defined as systolic blood pressure of 140 mmHg or higher, diastolic blood pressure of 90 mmHg or higher, or use of an antihypertensive drug. Among participants whose vitamin E intake was among the top one-third of subjects, there was a 27% lower risk of hypertension, and for those among the middle third, the risk was 19%lower. Adjustment for increased intake of other blood pressure-lowering nutrients failed to significantly affect the results. Editor’s Note:“Oxidative damage and free-radical production in the endothelium are closely involved in the pathogenesis of the atherosclerotic process which leads to cardiovascular disease,” Dr. Kuwabara and colleagues explain. “Since vitamin E is a fat-soluble vitamin with potent activity and one of its main physiological roles is considered to be the inhibition of unsaturated fatty acid oxidation, vitamin E is a promising candidate against oxidative stress-induced unfavorable consequences.” * J Nutr Sci Vitaminol (Tokyo).2014;60(4):239-45.

 27/12/2015   L’esposizione ad antibiotici macrolidi influenza il rischio di morte cardiaca e di aritmia   Una meta-analisi ha mostrato che l'uso di antibiotici macrolidi può essere associato a un leggero aumento del rischio di morte improvvisa o di aritmie ventricolari. I rischi assoluti di morte cardiaca improvvisa e di morte cardiaca sono piccoli, e quindi dovrebbero probabilmente avere un effetto limitato nella pratica clinica. Tuttavia, dato che i macrolidi sono antibiotici ampiamente prescritti, il numero totale di morti cardiache improvvise o di tachiaritmie ventricolari e di morti cardiache potrebbe essere non-trascurabile. E’stato esaminato in modo retrospettivo un campione di 33 studi pubblicati che ha coinvolto quasi 21 milioni di partecipanti. Gli endpoint primari erano morte cardiaca improvvisa o tachiaritmie ventricolari, e l'esito secondario era la morte cardiovascolare e la mortalità per qualsiasi causa. L'analisi statistica dei dati aggregati ha rivelato un aumento del rischio di morte cardiaca improvvisa o di tachiaritmie ventricolari ( RR=2.42; 95% IC, 1.61-3.63 ) tra i pazienti che assumono macrolidi. Simili aumenti sono stati osservati quando è stato presa in considerazione solo la morte cardiaca improvvisa ( RR=2.52; 95% IC, 1.91-3.31 ), e la morte cardiovascolare ( RR=1.31; IC 95%, 1.06-1.62 ). Nessuna relazione, tuttavia, è stata osservata tra l'uso di antibiotici macrolidi e la mortalità per tutte le cause o qualsiasi evento cardiovascolare. Gli incrementi del rischio variavano tra diversi tipi di macrolidi, con l'eccezione della Roxitromicina. Questi risultati si traducono in un aumento del rischio assoluto stimato di 118.1 morti cardiache improvvise o tachiaritmie ventricolari aggiuntive, e 38.2 ulteriori morti cardiovascolari per 1 milione di cicli di trattamento. I risultati di questa meta-analisi hanno indicato che i macrolidi possono essere associati a un significativo aumento del rischio di morte cardiaca improvvisa o di tachiaritmia ventricolare, e di morte cardiovascolare, ma non della mortalità per qualsiasi causa. Sono necessari ampi studi controllati e randomizzati per chiarire ulteriormente la sicurezza cardiovascolare dei macrolidi. ( Xagena2015 ) Fonte: Journal of American College of Cardiology, 2015

 16/11/2015   Riduzione della pressione arteriosa nell'Ipertensione   Una riduzione intensiva della pressione al di sotto dei target attualmente raccomandati garantisce una maggiore protezione vascolare, soprattutto nei soggetti ad elevato rischio di patologie cardiovascolari. Questo dato deriva dalla revisione con meta-analisi di 19 studi, per un totale di più di 45.000 pazienti, effettuata da Xinfang Xie del Peking University First Hospital di Beijing, secondo cui questa pratica porta ad una riduzione di eventi cardiovascolari maggiori, ictus, infarti miocardici, albuminuria e progressione della retinopatia, ma non ha alcun impatto su insufficienza cardiaca, mortalità per cause cardiovascolari, mortalità totale o nefropatie terminali rispetto ai regimi meno invasivi. I nuovi dati mettono in discussione il recente rilassamento dei target pressori per alcune popolazioni ad alto rischio nelle recenti linee guida JNC8 ed ESC/ESH. Secondo la presente revisione, la terapia aggressiva potrebbe essere di beneficio anche nei pazienti ad alto rischio con una pressione sistolica inferiore a 140 mmHg, e le attuali linee guida andrebbero revisionate di conseguenza. Alcuni esperti, comunque, affermano che la revisione non rappresenta tutte le evidenze disponibili sulla riduzione della pressione, dato che ha preso in considerazione soltanto una piccola quantità di studi che hanno specificamente esaminato pazienti anziani e diabetici e, inoltre, gli studi esaminati erano eterogenei sia nelle popolazioni osservate che nei target pressori. Fonte: Lancet online 2015, pubblicato il 6/11

 22/09/2015  The importance of vessel factors for stent deployment in diseased arteries  Abstract Finite element analyses have been carried out to investigate the effects of plaque thickness, plaque asymmetry and artery curvature on stent deployment in stenotic arteries. The Xience stent, one of the latest commercial metallic stents, was considered and its expansion was controlled by the inflation of a folded balloon. Results showed that it became a challenge to open arteries with thick plaque via stent expansion, as stresses and recoiling increased considerably with the increasing level of stenosis. Asymmetric plaque caused non-uniform stent expansion and uneven dogboning effect, with considerably high levels of vessel wall stresses developed in the regions covered by relatively thin layer of plaque. In a curved artery, a reduction in stent expansion was observed with the increase of artery curvature, accompanied by an elevation of stresses in the plaque and arterial layers. Consequently, particular care should be taken when implanting stents in diseased arteries with severe stenosis, unevenly distributed plaque layer and sharp curvature, as tissue damage might occur due to non-uniform expansion of the system. (Alessandro Schiavone,Wolfson Building, Loughborough University, Ashby Road, Loughborough, Leicestershire, United Kingdom. Journal of Integrative Cardiology.DOI: 10.15761/JIC.1000130)

 







 

 
 



Fellow of European Society of Cardiology
 



Fellow of the Society for Cardiovascular Angiography and Interventions (SCAI)
 



Fellow American College of Chest Phyisicians
 




FELLOW GISE,Società italiana di Cardiologia Invasiva
 



Fellow ANMCO

 


 
Altre Informazioni

 
 
 
 
 
 
 
 
 
 
 
Dal 1/01/2005 il sito è stato visitato 281874 volte  •  Utenti Connessi 77  • Accessi del giorno 6     Who links to my website?
   Tutti i diritti sono riservati © by Massimo Fioranelli   –  Ultima Modifica SITO effettuata il 03/02/2016
   Test Environment: Browser: IE - Monitor resolution settings: 1680x1050